Synthesis of Hydroxymethylenebisphosphonic Acid Derivatives in Different Solvents.
نویسندگان
چکیده
The syntheses of hydroxymethylenebisphosphonic acid derivatives (dronic acid derivatives) starting from the corresponding substituted acetic acids and P-reagents, mainly phosphorus trichloride and phosphorous acid are surveyed according to the solvents applied. The nature of the solvent is a critical point due to the heterogeneity of the reaction mixtures. This review sheds light on the optimum choice and ratio of the P-reactants, and on the optimum conditions.
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ورودعنوان ژورنال:
- Molecules
دوره 21 8 شماره
صفحات -
تاریخ انتشار 2016